Alzheimer's disease (AD) represents the leading cause for senile dementia affecting more than 4 million people worldwide. AD patients display a triad of pathological features including brain atrophy caused by neuronal loss, h-amyloid plaque and neurofibrillary tangles. We previously show that Cyclin
β¦ LIBER β¦
The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease
β Scribed by Yoshitaka Tatebayashi; Moon H. Lee; Liang Li; Khalid Iqbal; Inge Grundke-Iqbal
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 485 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0001-6322
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## Abstract The dentate gyrus is part of the hippocampal memory system and special in that it generates new neurons throughout life. Here we discuss the question of what the functional role of these new neurons might be. Our hypothesis is that they help the dentate gyrus to avoid the problem of cat
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