Gait analysis detects early changes in transgenic SOD1(G93A) mice
โ Scribed by Christine M. Wooley; Roger B. Sher; Ajit Kale; Wayne N. Frankel; Gregory A. Cox; Kevin L. Seburn
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 170 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0148-639X
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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that involves motoneuron degeneration, paralysis, and death. Mutations in Cu, Zn superoxide dismutase (SOD1) are one cause of this disease. It has been a puzzle as to why mutations in SOD1, an enzyme expressed in many neuronal
## Abstract Mutations in the superoxide dismutase 1 (SOD1) gene are associated with familial amyotrophic lateral sclerosis (ALS), and the SOD1^G93A^ transgenic mouse has been widely used as one animal model for studies of this neurodegenerative disorder. Recently, several reports have shown that ab
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder involving the selective degeneration of motor neurons. In a small proportion of patients, ALS is caused by mutations in copper/zinc superoxide dismutase (SOD1), and mice overexpressing SOD1 G93A mutant develop a syndrome that close