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DJ-1 Changes in G93A-SOD1 Transgenic Mice: Implications for Oxidative Stress in ALS

✍ Scribed by Nirit Lev; Debby Ickowicz; Yael Barhum; Eldad Melamed; Daniel Offen

Publisher: Humana Press Inc
Year: 2008
Tongue: English
Weight: 366 KB
Volume: 38
Category: Article
ISSN: 0895-8696
DOI: 10.1007/s12031-008-9138-7

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Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder involving the selective degeneration of motor neurons. In a small proportion of patients, ALS is caused by mutations in copper/zinc superoxide dismutase (SOD1), and mice overexpressing SOD1 G93A mutant develop a syndrome that close