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GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine

โœ Scribed by Madina R Gerasimov; Wynne K Schiffer; Eliot L Gardner; Douglas A Marsteller; Ian C Lennon; Stephen J.C Taylor; Jonathan D Brodie; Charles R Ashby Jr.; Stephen L Dewey


Book ID
114013746
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
74 KB
Volume
414
Category
Article
ISSN
0014-2999

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Previously, we demonstrated that gamma vinyl-GABA (GVG, Vigabatrin) dose-dependently inhibits cocaine-induced increases in dopamine (DA) concentrations in both the rodent and primate brain. Furthermore, it abolishes cocaine self-administration and conditioned place preference, while having no effect