We examined the acute effect of the irreversible GABA-transaminase inhibitor, gamma-vinyl GABA (GVG, Sabril , Vigabatrin ) on increases in nucleus accumbens (NAc) dopamine (DA) following acute administration of methamphetamine, heroin, or ethanol. Methamphetamine (2.5 mg/kg) produced a dose-dependen
✦ LIBER ✦
Sub-chronic low dose γ-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine
✍ Scribed by Wynne K. Schiffer; Douglas Marsteller; Stephen L. Dewey
- Book ID
- 105880412
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 198 KB
- Volume
- 168
- Category
- Article
- ISSN
- 0033-3158
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Previously, we demonstrated that gamma vinyl-GABA (GVG, Vigabatrin) dose-dependently inhibits cocaine-induced increases in dopamine (DA) concentrations in both the rodent and primate brain. Furthermore, it abolishes cocaine self-administration and conditioned place preference, while having no effect