Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT 1A -receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these
✦ LIBER ✦
RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine
✍ Scribed by Loren H. Parsons; George F. Koob; Friedbert Weiss
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 63 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0887-4476
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## Abstract We reported previously that (__S__)‐5‐[3‐[(1,4‐benzodioxan‐2‐ylmethyl)amino]propoxy]‐1,3‐benzodioxole hydrochloride (MKC‐242) (3 mg kg^−1^, i.p.), a selective 5‐HT~1A~ receptor agonist, accelerated the re‐entrainment of hamster wheel‐running rhythms to a new 8 hr delayed or advanced lig