G2 chromosomal radiosensitivity of ataxia-telangiectasia heterozygotes
โ Scribed by Ram Parshad; Katherine K. Sanford; Gary M. Jones; Robert E. Tarone
- Book ID
- 119103117
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 353 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
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Ataxia-telangiectasia (A-T) is an autosomal recessive disease involving chromosomal instability, susceptibility to cancer and X-ray hypersensitivity. The latter two features are expressed to a limited extent in the heterozygous carriers of A-T mutations. Although fibroblast lines from A-T heterozygo
X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles-namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In a