G2 chromosomal radiosensitivity in ataxia telangiectasia lymphocytes
โ Scribed by M.A. Bender; J.M. Rary; R.P. Kale
- Book ID
- 113192796
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 586 KB
- Volume
- 152
- Category
- Article
- ISSN
- 0027-5107
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Ataxia-telangiectasia (A-T) is an autosomal recessive disease involving chromosomal instability, susceptibility to cancer and X-ray hypersensitivity. The latter two features are expressed to a limited extent in the heterozygous carriers of A-T mutations. Although fibroblast lines from A-T heterozygo
X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles-namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In a