TriCyclic triazolocephem and triazolopenam csxboqlic acids have been synthesised, but only the former exhibited antibacterial activity. ## Triazolocephems of type (1) have been shown 2 to possess a level of antibacterial activity that wss of sufficient interest for the investigation to be extende
Fused β-lactams via intramolecular dipolar cycloaddition
✍ Scribed by K.S.Keshava Murthy; Alfred Hassner
- Book ID
- 108382819
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 222 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A stereoselective two step sequence for the construction of fused pyrrolidone ring systems has been developed which features the intramolecular [3+2] dipolar cycloaddition of unsaturated azomethine ylides. The ylides are produced upon reaction of aminomethylphosphonates with so-olefimic aldehydes, f
In 1950 Sheehan and Bose2 reported a convenient synthesis of 4,4-dicarboxy-2-azetidinone p by the cyclization of d-haloamidomalonates 1. The intermediate 1 is readily available by the acylation of aminomalonates with a suitable u-halo acid but since this method cannot be extended to the preparation