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Synthesis of polycyclic lactams via intramolecular dipolar cycloadditions of stabilized azomethine ylides

โœ Scribed by Stephen F. Martin; Tom H. Cheavens

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
238 KB
Volume
30
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A stereoselective two step sequence for the construction of fused pyrrolidone ring systems has been developed which features the intramolecular [3+2] dipolar cycloaddition of unsaturated azomethine ylides. The ylides are produced upon reaction of aminomethylphosphonates with so-olefimic aldehydes, followed by oxidative removal of the phosphonate ester group using a newly developed method.

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