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Further studies on the differentiation of a cell line of myeloid leukemia

โœ Scribed by Yasuo Ichikawa

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
871 KB
Volume
76
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

Abstract

A limited time of contact with a conditioned medium from embryo cells induced phagocytotic activity in a cell line of myeloid leukemia followed by the loss of colony forming and leukemogenic capacity. After two days in a high concentration of the conditioned medium, the colonies showed morphological changes which indicated the differentiation of this line of cells. The differentiationโ€stimulating factor present in the conditioned medium was relatively thermolabile, while the growthโ€stimulating factor was highly thermostable. Both factors could pass through a dialysis membrane.

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