✦ LIBER ✦

Differentiation of a cell line of myeloid leukemia

✍ Scribed by Yasuo Ichikawa

Publisher: John Wiley and Sons
Year: 1969
Tongue: English
Weight: 973 KB
Volume: 74
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040740303

No coin nor oath required. For personal study only.

✦ Synopsis

A cell line was established in vitro from a spontaneous myeloid leukemia of SL strain mice. This cell line was cytologically identified as myeloblast, and its normal differentiation appeared to be completely blocked in mass culture. When the line cells were seeded in soft agar with a conditioned medium from normal cells, either macrophages or neutrophil granulocytes appeared from a single clone. The rate of formation of colonies containing differentiated cells always increased with an increase in the concentration of conditioned medium. The conditioned medium from this line cell was not as effective as was that from normal cells in inducing differentiation.

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