Further studies of the effect of the T locus in the house mouse on male fertility

✍ Scribed by Braden, A. W. H. ;Gluecksohn-Waelsch, S.

• Publisher: John Wiley and Sons
• Year: 1958
• Tongue: English
• Weight: 984 KB
• Volume: 138
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1401380303

✦ Synopsis

Since the discovery of the recessive lethal mutation to as reported by Dobrovolskaia-Zawadskaia and Kobozieff ( '32) and Chesley and Dunn ('36) a considerable amount of research has been devoted to the remarkable series of recessive mutant alleles that have since been shown to occur at this locus (T). These t alleles are characterized by the production of taillessness when present in combination with the dominant allele Brachyury (T) which by itself (+/T) causes only a shortening of the tail. Up to date at least 9 different t alleles have been described as occurring in laboratory stocks and a further 16 alleles have been reported in wild populations (Dunn '56). Many, but not all, of these alleles are lethal when present in homozygous condition. Two unusual phenomena connected with the t alleles are (1) the existence of sterility in males carrying certain combinations of alleles, whereas females having similar genotypes are fully fertile (Bryson, '44 ; Dunn and Gluecksohn-Schoenheimer, '43 ; Gluecksohn-Schoenheimer, Segal and Fitch, '50) and (2) the abnormal segregation ratio of + and t, or T and t, in males,