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Effect of purified zona antibody on fertilization in the mouse

✍ Scribed by Tsunoda, Y. ;Sugie, T. ;Mori, J. ;Isojima, S. ;Koyama, K.

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 375 KB
Volume: 217
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402170111

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Bivalent (IgG) rabbit anti‐mouse zona pellucida antibody completely inhibited fertilization in the mouse. Univalent (Fab) zona antibody did not inhibit the fertilizability of eggs. However, the treatment or injection with anti‐rabbit IgG serum inhibited the fertilizability of eggs pretreated with antiserum Fab or eggs from females injected with antiserum Fab. It is concluded that the inhibition of fertilization by bivalent mouse zona antibody depends on the possibility that the antisera are directed against the zona as a whole and not specifically against the receptors for the Sperm.

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