Embryological tests of genetic male sterility in the house mouse

✍ Scribed by Gluecksohn-Schoenheimer, S. ;Segal, Ruth ;Fitch, Naomi

• Publisher: John Wiley and Sons
• Year: 1950
• Tongue: English
• Weight: 568 KB
• Volume: 113
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1401130307

✦ Synopsis

I n previous papers the existence of male sterility in the house mouse caused hy the combination of diff erent recessive mutations of the t type was reported (Eryson, '44; Dunn and Gluecksohn-Schoenheimer, '43). These mutations all occur in one linkage group (no. TX) and do not show any crossing o r e r with each other. Three of them have been shown to suppress crossing over in a region of 1-5 crossover units in chromosome IX and they all are probably coniiected with chromosonial rearrangernents of one kind or another.

The first mutation of this kind to be discovered was t o (Chesley and Dunn, '36). I n combiiiatioii with T (dominant short tail mutation) it produces taillessness, while in homozygous condition ( t " / V ) it is lethal and t O / P embryos die soon after implantation in the uterus. another recessive mutation related closely to t" is tl ; it also produces taillessness in combination with T and is lethal when homozygous, the tl/fl zygotes d j k g even before implantation ; the combination t"/t', however, resnlts in normal tailed progeny (Dunn, '37). While such normal tailed females t o / t l breed normally, the males are sterile (Dunn arid Gluecksoliii-Schoenheimer, '43). 9 third mutation in this series (t') turned out to be identical with t' (Dunn, '39). Recently, still another mutation in this series ( P I was analyzed. It also produces taillessness in conibinanation with T a i d does not show any crossing over with the other mutatioiis in the l' series, lout the homozygotes ( i 3 / t 3 )

This work was aidcd by n grant froin the American Cancer Society o n the recommendation of the Coriirriittce on Growth of the National Research Council.