Further applications of the 4-(methylthio)-phenyl ester in peptide chemistry
โ Scribed by Brian J. Johnson; Daniel E. Tracey
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 93 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
The Mitsunobu reaction ยฑ the nucleophilic substitution of an alcoholic hydroxyl group mediated by the redox system trialkylphosphine/dialkyl azodicarobxylate ยฑ is widely used in the chemistry of biologically active compounds. The paper deals with applications of the Mitsunobu reaction in amino acid
In order to eliminate the problems associated witb the use of alkali during peptide synthesis, a systematic investigation was catried out to lengthen pe tide chains by cou ling N-protected pentachlorophenyl active esters of a d n o acix and peptides w d amino acids and peptides, C-protected by dicyd