The Mitsunobu reaction ยฑ the nucleophilic substitution of an alcoholic hydroxyl group mediated by the redox system trialkylphosphine/dialkyl azodicarobxylate ยฑ is widely used in the chemistry of biologically active compounds. The paper deals with applications of the Mitsunobu reaction in amino acid
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ChemInform Abstract: Applications of the Mitsunobu Reaction in Peptide Chemistry
โ Scribed by K. WISNIEWSKI; A. S. KOLDZIEJCZYK; B. FALKIEWICZ
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 25 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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Alkylation of Pyrazolones via the Mitsunobu Reaction. -Mitsunobu coupling of pyrazolinone (I) or 4-acylated analogues with simple alcohols results in a preferred or exclusive O-alkylation depending on the solvent used. This mild and effective method allows the preparation of products which are not