ChemInform Abstract: Alkylation of Pyrazolones via the Mitsunobu Reaction.

✍ Scribed by W. HOLZER; B. PLAGENS; K. LORENZ

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199734134

✦ Synopsis

Alkylation of Pyrazolones via the Mitsunobu Reaction.

-Mitsunobu coupling of pyrazolinone (I) or 4-acylated analogues with simple alcohols results in a preferred or exclusive O-alkylation depending on the solvent used.

This mild and effective method allows the preparation of products which are not or not readily available with conventional alkylation procedures. -(HOLZER, W.;