ChemInform Abstract: Application of the Mitsunobu Reaction in the Field of Alkaloids
โ Scribed by C. SIMON; S. HOSZTAFI; S. MAKLEIT
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 24 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
The Mitsunobu reaction ยฑ the nucleophilic substitution of an alcoholic hydroxyl group mediated by the redox system trialkylphosphine/dialkyl azodicarobxylate ยฑ is widely used in the chemistry of biologically active compounds. The paper deals with applications of the Mitsunobu reaction in amino acid
Alkylation of Pyrazolones via the Mitsunobu Reaction. -Mitsunobu coupling of pyrazolinone (I) or 4-acylated analogues with simple alcohols results in a preferred or exclusive O-alkylation depending on the solvent used. This mild and effective method allows the preparation of products which are not