Synthesis and biological evaluation of f
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Yisheng Lai; Lihong Shen; Zhenzhen Zhang; Wenqing Liu; Yihua Zhang; Hui Ji; Jide
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Article
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2010
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Elsevier Science
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English
β 463 KB
A series of novel furoxan-based nitric oxide (NO)-releasing derivatives of glycyrrhetinic acid (GA) were designed, synthesized, and evaluated for their in vitro cytotoxicity against human hepatocellular carcinoma (HCC) and non-tumor liver cells. Five furoxan/GA hybrids, 7b-d, 7f, and 7g, displayed p