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Furaquinocins A-G: relative and absolute stereochemistry

✍ Scribed by Peter G. Dormer; Amos B. Smith III; Shinji Funayama; Satoshi Omura

Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
292 KB
Volume
33
Category
Article
ISSN
0040-4039

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✦ Synopsis

The complete relative and absolute stereochemistry of furaquinocins A-G, a family of cytotoxic antibiotics, have been assigned via a combination of X-ray crystallography, NMR analysis of the derived Mosher esters, and chemical correlation. Komiyama et al. at the Kitasato Institute recently reported the isolation, physicochemical, and biological characteristics of furaquinocins A (1) and B {2). 1 These novel antibiotics, obtained from the fermentation broth of Streptomyces sp. KO-3988, exhibited strong

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