𝔖 Bobbio Scriptorium
✦   LIBER   ✦

(+)-Mycotrienins I and II: Relative and Absolute Stereochemistry

✍ Scribed by Amos B. Smith III; John L. Wood; Satoshi Ōmura

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
140 KB
Volume
32
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The complete relative and absolute stereochemistry of the potent antrfungal antrbrotrcs (+)-mycotriemn I and (+)-mycotrienrn II have been established by chemrcal correlation with the antltumor agent (+)-tnenomycin A Recently, Umezawa and coworkers reported the isolatron of several ansamycin antibiotics from the culture broth of Streptomyces sp. No. 83-16.' Termed the trrenomyctns, these compounds exhibited strong fn vifro cytotoxicity against HeLa Ss cells 2 The most active and most abundant congener, (+)-trienomyctn A (l), had been found earlier as a minor constituent of the 5' nshiriensis T-23 fermentation broth,3 which furmshed as the major components (+)-mycotnenins I and

📜 SIMILAR VOLUMES

(+)-Thiazinotrienomycin E: Relative and
(+)-Thiazinotrienomycin E: Relative and absolute stereochemistry
✍ Amos B Smith III; Joseph Barbosa; Nobuo Hosokawa; Hiroshi Naganawa; Tomio Takeuc 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 185 KB

The complete relative and absolute configurations of (+)-thiazinotrienomycin E, a potent new ansatrienin cancer cell growth inhibitory agent, have been determined via degradation and chemical correlation.

Furaquinocins A-G: relative and absolute
Furaquinocins A-G: relative and absolute stereochemistry
✍ Peter G. Dormer; Amos B. Smith III; Shinji Funayama; Satoshi Omura 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 292 KB

The complete relative and absolute stereochemistry of furaquinocins A-G, a family of cytotoxic antibiotics, have been assigned via a combination of X-ray crystallography, NMR analysis of the derived Mosher esters, and chemical correlation. Komiyama et al. at the Kitasato Institute recently reported