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Fundamental differences in the interactions of stabilizing solutes with proteins during freeze-thawing versus during freeze-drying

โœ Scribed by J.F. Carpenter; J.H. Crowe


Book ID
115850873
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
228 KB
Volume
25
Category
Article
ISSN
0011-2240

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The purpose of this study is to investigate the mechanism of protein stabilization by sugars in the solid state. That is, explore whether the stabilization is controlled by "glass dynamics" or by native structure preservation through "specific interaction" between sugars and protein. The IgG1 antibo