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Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

✍ Scribed by Jackson, Stephen P.; Fagagna, Fabrizio d'Adda di; Hande, M. Prakash; Tong, Wei-Min; Lansdorp, Peter M.; Wang, Zhao-Qi

Book ID
109494738
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
388 KB
Volume
23
Category
Article
ISSN
1061-4036

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## Abstract Amyloid peptide is thought to play a critical role in neuronal death in Alzheimer's disease (AD), most likely through oxidative stress. Free radical‐related injury leads to DNA breaks, which subsequently activates the repair enzyme poly(ADP‐ribose) polymerase‐1 (PARP‐1). In this study,