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Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice

✍ Scribed by Mitsuko Matsutani; Tadashige Nozaki; Eiko Nishiyama; Takashi Shimokawa; Yumiko Tachi; Hiroshi Suzuki; Hitoshi Nakagama; Keiji Wakabayashi; Takashi Sugimura


Book ID
110244329
Publisher
Springer
Year
1999
Tongue
English
Weight
73 KB
Volume
193
Category
Article
ISSN
0300-8177

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Poly(ADP-ribose) polymerase in DNA damag
✍ Viatcheslav A. Soldatenkov; Mark Smulson 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

Poly(ADP-ribose) polymerase (PARP) catalyzes the transfer of successive units of ADP-ribose moiety from NAD ؉ covalently to itself and other nuclear acceptor proteins. PARP is a zinc finger-containing protein, allowing the enzyme to bind to either double-or single-strand DNA breaks without any appar