Poly(ADP-ribose) polymerase in DNA damag
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Viatcheslav A. Soldatenkov; Mark Smulson
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Article
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2000
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John Wiley and Sons
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French
⚖ 301 KB
Poly(ADP-ribose) polymerase (PARP) catalyzes the transfer of successive units of ADP-ribose moiety from NAD ؉ covalently to itself and other nuclear acceptor proteins. PARP is a zinc finger-containing protein, allowing the enzyme to bind to either double-or single-strand DNA breaks without any appar