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Functional inactivation of the WTX gene is not a frequent event in Wilms’ tumors

✍ Scribed by Perotti, D; Gamba, B; Sardella, M; Spreafico, F; Terenziani, M; Collini, P; Pession, A; Nantron, M; Fossati-Bellani, F; Radice, P

Book ID
109970888
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
303 KB
Volume
27
Category
Article
ISSN
0950-9232

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## Abstract Wilms tumor (WT) is one of the most common solid tumors in childhood. Mutations in __WT1__ and __CTNNB1__ are well established as causal alterations in about 10–15% of cases. Recently, __WTX__ (WT gene on the X‐chromosome), a gene implicated in WNT signaling, has been identified as a th

The QM gene is X-linked and therefore no
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✍ Ans M. W. Ouweland; Marian Verdijk; Marcel M. A. M. Mannens; Bernard A. Oost 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 349 KB

Inactivation of one or more tumor-suppressor genes on the short arm of chromosome 11 is thought to play a role in the etiology of Wilms' tumor. A candidate gene, QM, was recently isolated by subtractive hybridization between a tumorigenic cell line (deleted for part of 11p) and a non-tumorigenic cel