The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor

✍ Scribed by Ans M. W. Ouweland; Marian Verdijk; Marcel M. A. M. Mannens; Bernard A. Oost

• Book ID: 104666252
• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 349 KB
• Volume: 90
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00210759

✦ Synopsis

Inactivation of one or more tumor-suppressor genes on the short arm of chromosome 11 is thought to play a role in the etiology of Wilms' tumor. A candidate gene, QM, was recently isolated by subtractive hybridization between a tumorigenic cell line (deleted for part of 11p) and a non-tumorigenic cell line (the tumorigenic cell line carrying an extra t(X;11)copy). We show here with an exon-specific polymerase chain reaction that the genomic homolog of the QM cDNA is located in the G6PD-color vision genes region in Xq28. No homologous sequences could be detected on 11p. Our experiments indicate that the QM gene is not involved in the suppression of Wilms' tumor.