Functional dissection of transformation by c-Src and v-Src
✍ Scribed by Chitose Oneyama; Tomoya Hikita; Shigeyuki Nada; Masato Okada
- Book ID
- 108731983
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 417 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1356-9597
No coin nor oath required. For personal study only.
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## Abstract The insulin receptor substrate‐1 (IRS‐1), a docking protein for both the insulin (InR) and the insulin‐like growth factor‐1 (IGF‐IR) receptors, sends a mitogenic, anti‐differentiation and transforming signal. We now show that down‐regulation of IRS‐1 in cells transformed by v‐src revers
v-src±transformed fibroblasts have significantly reduced levels of gap junction±mediated intercellular communication. This observed downregulation of cellular communication has been associated with tyrosine phosphorylation of the gapjunction protein connexin 43 (Cx43). Previously, we demonstrated th