𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The role of insulin receptor substrate-1 in transformation by v-src

✍ Scribed by Hongzhi Sun; Renato Baserga

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
373 KB
Volume
215
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The insulin receptor substrate‐1 (IRS‐1), a docking protein for both the insulin (InR) and the insulin‐like growth factor‐1 (IGF‐IR) receptors, sends a mitogenic, anti‐differentiation and transforming signal. We now show that down‐regulation of IRS‐1 in cells transformed by v‐src reverses the transformed phenotype (growth in serum‐free medium and colony formation in soft agar). IRS‐1 translocates to nuclei and is found in the cyclin D1 and rDNA promoters. Stat3, which is activated by src, requires both IRS‐1 and src for promoter occupancy. IRS‐1 (by itself or in combination with src) also markedly increases transcription from these two promoters. We also show that IRS‐1 binds to src via its two PI3‐K binding tyrosine residues, and that these two residues are required for transformation of mammary cancer cells expressing v‐src. Taken together, these results indicate a significant role of IRS‐1 in the activation of cell cycle progression genes and transformation of cells by v‐src. J. Cell. Physiol. 215: 725–732, 2008. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Nuclear translocation of insulin recepto
Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts
✍ An Wu; Laura Sciacca; Renato Baserga 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 300 KB

## Abstract Translocation of the insulin receptor substrate‐1 (IRS‐1) to the nuclei has been reported to occur in cells stimulated by insulin‐like growth factor‐1 (IGF‐I) or expressing certain viral and cellular oncogenes. We show here that insulin can also induce nuclear translocation of IRS‐1 in

The insulin sensitivity response is dete
The insulin sensitivity response is determined by the interaction between the G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat
✍ Carmen Marín; Pablo Pérez-Martínez; Javier Delgado-Lista; Purificación Gómez; Fe 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB

## Abstract **Scope**: Insulin resistance, a condition associated with type 2 diabetes mellitus, results from the interaction of environmental and genetic factors. The aim of this study was to explore the influence of the G972R polymorphism at the insulin receptor substrate 1 gene on insulin sensit

Rapamycin-resistant phosphorylation of t
Rapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-SRC-transformed hamster fibroblasts
✍ Zdena Tuháčková; Vlasta Sovová; Eva Šloncová; Christopher G. Proud 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 187 KB 👁 1 views

Increased phosphorylation of the translational repressor protein 4E-BP1 was found in the cell line derived from the tumor induced in Syrian hamster by Rous sarcoma virus (RSV). This was accompanied by its dissociation from the complex with initiation factor eIF4E. The ribosomal S6 protein kinase p70

Role of the insulin-like growth factor 1
Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma
✍ C. L. Donohoe; S. L. Doyle; S. McGarrigle; M. C. Cathcart; E. Daly; A. O'Grady; 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 296 KB 👁 2 views

## Abstract ## Background Epidemiological studies have linked obesity with many cancers. The insulin-like growth factor (IGF) 1 axis may be an important mediator in obesity-associated cancer. This study examined the relationship between IGF-1 and its receptor (IGF-1R) in oesophageal adenocarcinoma