The insulin sensitivity response is determined by the interaction between the G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat
✍ Scribed by Carmen Marín; Pablo Pérez-Martínez; Javier Delgado-Lista; Purificación Gómez; Fernando Rodríguez; Elena María Yubero-Serrano; Antonio García-Ríos; Antonio Camargo; Francisco Pérez-Jiménez; José López-Miranda
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 156 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1613-4125
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Scope: Insulin resistance, a condition associated with type 2 diabetes mellitus, results from the interaction of environmental and genetic factors. The aim of this study was to explore the influence of the G972R polymorphism at the insulin receptor substrate 1 gene on insulin sensitivity in a healthy young population. Furthermore, we examined whether the presence of this single nucleotide polymorphism (SNP; GR or GG) interacts with dietary fat to modulate insulin sensitivity.
Methods and results: Fifty‐nine healthy volunteers consumed three diets during 4 wk each following a randomized crossover design: a saturated fatty acid diet, a low‐fat and high carbohydrate (CHO) diet or a MUFA diet. For each diet, we investigated peripheral insulin sensitivity with the insulin suppression test. Steady‐state plasma glucose and plasma‐free fatty acids concentrations were significantly lower in GR subjects after the intake of a CHO diet, than did homozygous GG subjects (p<0.05). However, no differences were observed after consuming the two other diets.
Conclusions: Insulin sensitivity increased in GR subjects for the G972R polymorphism at the insulin receptor substrate 1 gene locus, after intake of a CHO diet. Increased knowledge of how these and other genes influence insulin sensitivity should increase the understanding of personalized nutrition.