Functional analysis of the osteoarthritis susceptibility–associated GDF5 regulatory polymorphism
✍ Scribed by Rainer J. Egli; Lorraine Southam; James M. Wilkins; Inken Lorenzen; Manuel Pombo-Suarez; Antonio Gonzalez; Andrew Carr; Kay Chapman; John Loughlin
- Book ID
- 101653654
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 190 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Genetic factors have been shown to play an important role in the etiology of osteoarthritis (OA). A functional single nucleotide polymorphism (SNP) +104T/C; rs143383 in the 5′ UTR of the GDF5 gene was recently associated with susceptibility to osteoarthritis in the Japanese and Chinese
## Abstract ## Objective __GDF5__ and __FRZB__ have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of the __GDF5__ gene or the rs7775 and rs288326 polymorphis