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Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α

✍ Scribed by Roberto Dominici; Monica Cattaneo; Giulia Malferrari; Davide Archi; Claudio Mariani; Luigi Grimaldi; Ida Biunno

Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
64 KB
Volume
54
Category
Article
ISSN
0093-7711

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Functional polymorphism in ALOX15 result
Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1
✍ Jonas Wittwer; Jacqueline Marti-Jaun; Martin Hersberger 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 274 KB

## Communicated by Stephen Chanock The reticulocyte-type 15-lipoxygenase-1 (ALOX15) has antiinflammatory and inflammatory effects, and is implicated in the development of asthma, arthritis, and atherosclerosis. We screened the human ALOX15 gene for variations because genetic variability in ALOX15