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A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis

✍ Scribed by Miyamoto, Yoshinari; Mabuchi, Akihiko; Shi, Dongquan; Kubo, Toshikazu; Takatori, Yoshio; Saito, Susumu; Fujioka, Mikihiro; Sudo, Akihiro; Uchida, Atsumasa; Yamamoto, Seizo

Book ID
109631529
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
185 KB
Volume
39
Category
Article
ISSN
1061-4036

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## Abstract Genetic factors have been shown to play an important role in the etiology of osteoarthritis (OA). A functional single nucleotide polymorphism (SNP) +104T/C; rs143383 in the 5′ UTR of the GDF5 gene was recently associated with susceptibility to osteoarthritis in the Japanese and Chinese