Fumonisin toxicity in a transgenic mouse model lacking the mdr1a/1b P-glycoprotein genes
β Scribed by Raghubir P Sharma; Neetesh Bhandari; Masashi Tsunoda; Ronald T Riley; Kenneth A Voss; Filmore I Meredith
- Book ID
- 117766026
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 276 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1382-6689
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π SIMILAR VOLUMES
## Abstract A subpopulation of the CFβ1 mouse strain is sensitive to neurotoxicity following exposure to avermectins, a family of structurally related antiparasitic agents. This unusual sensitivity is the result of a deficiency in the mdr1a Pβglycoprotein that normally contributes to a functional b
In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta