Frontiers in Protein Structure, Function, and Dynamics

✍ Scribed by Dev Bukhsh Singh, Timir Tripathi

• Publisher: Springer Singapore;Springer
• Year: 2020
• Tongue: English
• Leaves: 457
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances.

Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecular motors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction.

✦ Table of Contents

Front Matter ....Pages i-xii
Protein Purification, Estimation, Storage, and Effect on Structure–Function–Dynamics (Awanish Kumar)....Pages 1-22
Experimental and Computational Methods to Determine Protein Structure and Stability (Nachiappan Mutharasappan, Guru Ravi Rao, Richard Mariadasse, Saritha Poopandi, Amala Mathimaran, Prabhu Dhamodharan et al.)....Pages 23-55
Wet-Lab Approaches to Determine Three-Dimensional Structures of Proteins (Rajan Kumar Pandey, Rupal Ojha, Vijay Kumar Prajapati)....Pages 57-70
Use of Group-Specific Reagents in Active Site Functional Group Elucidation I: Cys, Ser, Tyr, and Trp Residues (Pravin Kumar Ambasht)....Pages 71-94
Use of Group-Specific Reagents in Active Site Functional Group Elucidation II: Asp, Glu, Arg, Lys, and His Residues (Pravin Kumar Ambasht)....Pages 95-117
Protein-Protein Interactions Modeling: From Dry to Wet Lab (Ekta Khare, Dev Bukhsh Singh)....Pages 119-143
Thermodynamics of Protein-Ligand Binding (Komal S. Khatri, Priya Modi, Shilpa Sharma, Shashank Deep)....Pages 145-185
Synergistic Effects of Hydration Sites in Protein Stability: A Theoretical Water Thermodynamics Approach (Jayashree Biswal, Prajisha Jayaprakash, Raghu Rangaswamy, Jeyaraman Jeyakanthan)....Pages 187-212
Molecular Dynamics Simulation: Methods and Application (Sakshi Singh, Vinay Kumar Singh)....Pages 213-238
Protein Folding, Dynamics and Aggregation at Single-Molecule Resolution (Ritobrita Chakraborty, Krishnananda Chattopadhyay)....Pages 239-258
Protein Misfolding and Neurodegenerative Diseases (Anand Narayan Singh, Nivedita Saxena, Manish Kumar Verma)....Pages 259-282
Management of Insulin Through Co-Solute Engineering: A Therapeutic Approach (Sania Bashir, Neha Sami, Sayema Bashir, Faizan Ahmad, Md. Imtaiyaz Hassan, Asimul Islam)....Pages 283-315
Structural and Functional Aspects of Muscarinic Receptors in Correlation with Anticholinergic Drugs (Pramod Kumar Singh, Rajendra Nath, Ram Naraian, Manish Kumar Gupta)....Pages 317-338
Dopamine Beta Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases (Swati Kundu, Manisha Saini, Sanjay Kumar Dey, Suman Kundu)....Pages 339-357
Molecular Motors: Subdomain Dynamics and Mechanochemistry (Meenakshi Singh, Sudhir Kumar Singh)....Pages 359-390
Structural and Functional Dynamics of Lysosomal Cysteine Proteases with Particular Reference to Cathepsin B and Cathepsin H (Sudhir K. Agarwal, Shalini Singh, Samir Sharma)....Pages 391-424
An Insight into the Importance of Ferritins in the Physiology of Mycobacterium tuberculosis: Unique Structural and Functional Properties (Garima Khare, Prachi Nangpal, Anil Kumar Tyagi)....Pages 425-452
Correction to: Structural and Functional Aspects of Muscarinic Receptors in Correlation with Anticholinergic Drugs (Pramod Kumar Singh, Rajendra Nath, Ram Naraian, Manish Kumar Gupta)....Pages C1-C1

✦ Subjects

Life Sciences; Protein Science; Protein Structure; Enzymology; Gene Function; Bioinformatics