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From penicillin to penem and carbapenem. IV Synthesis of 2-oxocarbapenam derivative

โœ Scribed by Koichi Hirai; Yuji Iwano; Katsumi Fujimoto

Book ID
104221500
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
194 KB
Volume
24
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Previously obtained 4-iodomethylazetidinone derivative (2a) is Recently same type of reaction was applied to the Ij-lactam field; S.Takano, C. Kasahara, and K. Ogasawara, Chem. m., 631 (1982). 10) T.N. Salzmann, R.W. Ratcliffe, B.G. Christensen, and F.A. Bouffard, J. Am. --_ _., HZ_, 6161 (1980). Chem. Sot

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โœ Marco Alpegiani; Angelo Bedeschi; Maurizio Foglio; Franco Giudici; Ettore Perron ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 245 KB

Displacement of different leaving groups from a number of 2-oxo-azetidin-4-ylthio derivatives with thioacids, followed by sulphur extrusion, provides a facile access to Blactam thioesters and hence to penems.