Desulphurative approaches to penem antibiotics. II. 4-acyldithioazetidin-2-ones from penicillin derived sulphenimides, thiolsulphonates and disulphides.

✍ Scribed by Marco Alpegiani; Angelo Bedeschi; Maurizio Foglio; Franco Giudici; Ettore Perrone

• Book ID: 104217178
• Publisher: Elsevier Science
• Year: 1983
• Tongue: French
• Weight: 245 KB
• Volume: 24
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)81728-1

✦ Synopsis

Displacement of different leaving groups from a number of 2-oxo-azetidin-4-ylthio derivatives with thioacids, followed by sulphur extrusion, provides a facile access to Blactam thioesters and hence to penems.