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Friedel-Crafts synthesis of 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone, a key intermediate in the preparation of the antidepressant sertraline

✍ Scribed by Quallich, George J.; Williams, Michael T.; Friedmann, Robert C.


Book ID
120640327
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
463 KB
Volume
55
Category
Article
ISSN
0022-3263

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Synthesis of 4-amino-3,4-dihydro-2(1H)-q
✍ Yazhong Pei; Richard A. Houghten; John S. Kiely πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 241 KB

The synthesis of 3,4-dihydro-2(IH)-quinolinones has been accomplished through the rearrangement of ~lactam intermediates on the solid-phase. The ~-laetam intermediates were constructed through [2+2] cycloadditions between ketenes and imines on the solid-phase. A library of 4,140 dihydroquinolinones