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Synthesis and X-Ray Crystal Structure Analysis of 4-(3,4-Dichlorophenyl)-2- (3,4,5-trimethoxy-benzylidene)-3,4-dihydro-naphthalen-1(2H)-one: Sertraline Key Intermediate Analogue.

✍ Scribed by Chandagirikoppal V. Kavitha; Kempegowda Mantelingu; Gangadaraiah Sarala; S. Naveen; Sridhar Anandalwar; Javaregowda Shashidhara Prasad; Kanchugarakoppal S. Rangappa


Publisher
John Wiley and Sons
Year
2007
Weight
18 KB
Volume
38
Category
Article
ISSN
0931-7597

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5(4H)-ones / 2-Chloro-N-cyanomethyl-N-methylnicotinamide / Aromatic nucleophilic substitution A new synthesis of pyrido[3,2-f][1,4]thiazepine derivatives 3 starting with 2-chloronicotinic acid (1), methylaminoacetonitrile hydrochloride and carbon disulfide is described. As proved by a crystal struct