Many tumors exhibit loss of heterozygosity (LOH) for polymorphic markers in regions of the genome that contain genes whose normal function can suppress tumor growth. Mapping of regions of LOH can help identify putative tumor suppressor loci that play a role in the pathogenesis of a disease. We evalu
Frequent loss of heterozygosity and three critical regions on the short arm of chromosome 8 in ovarian adenocarcinomas
β Scribed by Wright, K; Wilson, P J; Kerr, J; Do, K; Hurst, T; Khoo, S-K; Ward, B; Chenevix-Trench, G
- Book ID
- 110061512
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 259 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
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Loss of heterozygosity (LOH) was examined at 27 loci on chromosomes 3p, 6q, I Ip, 13q. 17 and X in 42 human ovarian tumors. LOH was detected in I 2 of 26 (46%) and 5 of I 2 (42%) informative cases at 2 chromosome 13q loci, D13S32 and D I3534 respectively. On chromosome Xp, tumor-specific allele loss
Loss of heterozygosity (LOH) from the short arm of chromosome 8 (8p) is common t o many human carcinomas, including those of the colon and prostate. It localizes to two discrete regions, 8p21 and 8p22. This suggests the presence of at least two tumor suppressor genes (TSGs) on this chromosome arm. H
## Abstract To identify the putative common deleted region on the long arm of chromosome 22 in pheochromocytoma, restriction fragment length polymorphism analysis was performed in 17 pheochromocytomas. All cases were heterozygous for at least one of the eight marker loci on 22q. Loss of heterozygos