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Frequent Loss of 9p21 (p16INK4A) and Other Genomic Imbalances in Human Malignant Fibrous Histiocytoma

✍ Scribed by Annet Simons; Marga Schepens; Judith Jeuken; Sandra Sprenger; Guillaume van de Zande; Bodil Bjerkehagen; Anne Forus; Vines Weibolt; Ineke Molenaar; Eva van den Berg; Ola Myklebost; Julia Bridge; Ad Geurts van Kessel; Ron Suijkerbuijk

Book ID: 114137029
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 317 KB
Volume: 118
Category: Article
ISSN: 0165-4608
DOI: 10.1016/s0165-4608(99)00178-8

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## Abstract The __p16__^INK4a^ gene, localized within chromosome 9p21, has been identified as a cyclin‐dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series

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