Cyclin-dependent kinillre-4 inhibitor genes (INK4) regulate the cell cycle and are candidate tumor-suppressor genes. To determine if alterations in the coding regions of the p18 and p l 9 genes, which are novel members of the INK4 family and if they correlate with the development of human cancer, 10
✦ LIBER ✦
Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-α1, interferon-β1, and other 9p21 markers in human malignant cell lines
✍ Scribed by Hongyang Zhang; Zhi-Hao Chen; Todd M. Savarese
- Book ID
- 113253614
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 904 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
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## Wild -type P16ICDKNZ MTSI) cDNA, directed by the cytomegalovirus (CMV) immediate early promoter, was transfected into RT4 and RTI I 2 bladder-carcinoma cell lines bearing a mutated endogenous P16ICDKNZ gene and lacking endogenous P 16lCDKN2 respectively. In both cases, only transfected clones w