## Abstract Difficulties in obtaining clinical samples from primary melanomas have meant that most genetic analyses of melanoma have concentrated on cell lines and metastases. Because the Breslow thickness of the primary tumour is the single best prognostic indicator, it is important to identify ge
Loss of heterozygosity of chromosome 9P21 and P16INK4a status in sporadic cutaneous melanoma
โ Scribed by Takata, Minoru; Fujimoto, Akihide; Morita, Reiji; Hatta, Naohito; Takehara, Kazuhiko
- Book ID
- 119562072
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 191 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0923-1811
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Chromosome 9p21 is frequently deleted in malignant melanoma, and one familial malignant melanoma gene has been linked to 9p21-22. Recently, the cyclin D-dependent kinase inhibitors (CDKIs) p16INK4a and p15INK4b have been localized within chromosome 9p21, and the presence of p16INK4a point mutations
Chromosome region 9p21 contains a tumor suppressor locus (p16) that may be involved in the genesis of several kinds of malignant tumors. To characterize the role of this gene in the development of soft-tissue tumors (STTs), we investigated the frequency of loss of heterozygosity (LOH) at this locus.