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Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma

✍ Scribed by Sarki A Abdulkadir; Joseph M Carbone; Cathy K Naughton; Peter A Humphrey; William J Catalona; Jeffrey Milbrandt


Book ID
117818470
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
515 KB
Volume
32
Category
Article
ISSN
1532-8392

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## Abstract Loss of heterozygosity (LOH) at chromosome 13q14 is one of the most recurrent anomalies observed in sporadic prostate tumors. This LOH is believed to unmask recessive mutations that inactivate a tumor‐suppressor gene(s) which otherwise regulates normal cell growth and suppresses abnorma