✦ LIBER ✦

Frequency scan for the analysis of high mass ions generated by matrix-assisted laser desorption/ionization in a Paul trap

✍ Scribed by Urs P. Schlunegger; Markus Stoeckli; Richard M. Caprioli

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 87 KB
Volume: 13
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(19990930)13:18<1792::aid-rcm715>3.0.co;2-s

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✦ Synopsis

An ion trap has been modified for the analysis of high mass ions generated by matrix-assisted laser desorption/ionization. Samples are deposited on a probe tip and introduced directly onto the hyperbolically shaped surface of one endcap. All three electrodes - both the endcaps and the ring electrode - are insulated so that the radio frequency (Rf) voltage may be applied to the center ring electrode and the inverted Rf voltage to the endcaps. By using low frequencies (below 100 kHz) and low amplitudes (below 200 V), high mass singly charged ions may be trapped and analyzed by a frequency sweep at constant amplitude. In the high mass range (60-160 kDa), this instrument showed good sensitivity, signal-to-noise ratios, and mass resolution. Copyright 1999 John Wiley & Sons, Ltd.

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