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Frequency and parental origin of de novo APC mutations in familial adenomatous polyposis

✍ Scribed by Aretz, Stefan; Uhlhaas, Siegfried; Caspari, Reiner; Mangold, Elisabeth; Pagenstecher, Constanze; Propping, Peter; Friedl, Waltraut


Book ID
110025497
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
144 KB
Volume
12
Category
Article
ISSN
1018-4813

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APC germline mutations identified in Cze
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## Communicated by Georgia Chenevix-Trench Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited predisposition to colorectal cancer, which is caused by germline mutations in the adenomatous polyposis coli (APC) gene. The APC mutations have been investigated in 46 Czech unrelat