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Frequencies of Sister Chromatid Exchanges in Bloom's Syndrome Fibroblasts

✍ Scribed by P. P. W. Van Bull; P. A. M. Vergegaal; A. T. Natarajan


Book ID
119838710
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
68 KB
Volume
14
Category
Article
ISSN
0009-9163

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Suppression of the frequencies of sister
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The effect of co-cultivation of Bloom's syndrome fibroblasts with Chinese hamster ovary cells (CHO) on the incidence of sister chromatid exchanges (SCEs) was studied. The results show that suppression of the frequency of SCEs in Bloom's syndrome cells occurs only if cell to cell contact is present w

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A comparison is made between the incidences of sister chromatid exchanges (SCE) per chromosome and group of chromosomes and breakage, visible at metaphase like open gaps, breaks, and breaks involved in chromatid interchange formation (CI) in Bloom's syndrome. It can be shown that the two levels of b

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Cocultivation of fibroblast cells from a male patient with Bloom syndrome (BS) and a female control reduced the rate of sister chromatid exchanges in the BS cells from a mean of 54 SCE per metaphase (range 42--65) to 41 (range 24--59). Medium used to culture control cells for 48 h also reduced the r