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Free Radical-Induced Tandem Base Damage in DNA Oligomers

โœ Scribed by Harold C Box; Edwin E Budzinski; Jean B Dawidzik; Jason S Gobey; Harold G Freund


Book ID
114276705
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
514 KB
Volume
23
Category
Article
ISSN
0891-5849

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DNA damage induced by oxygen radicals, e.g., hydroxyl radicals generated in living cells either by cellular metabolism or external agents such as ionizing radiations, appears to play an important role in mutagenesis, carcinogenesis, and aging. Elucidation of the chemical nature of such DNA lesions a