Antimutagenic role of base-excision repair enzymes upon free radical-induced DNA damage
β Scribed by Jacques Laval; Juan Jurado; Murat Saparbaev; Olga Sidorkina
- Book ID
- 114071480
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 106 KB
- Volume
- 402
- Category
- Article
- ISSN
- 0027-5107
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π SIMILAR VOLUMES
DNA damage induced by oxygen radicals, e.g., hydroxyl radicals generated in living cells either by cellular metabolism or external agents such as ionizing radiations, appears to play an important role in mutagenesis, carcinogenesis, and aging. Elucidation of the chemical nature of such DNA lesions a
Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals hav