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Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability

✍ Scribed by Min Sung Kim; Sung Soo Kim; Chang Hyeok Ahn; Nam Jin Yoo; Sug Hyung Lee

Book ID: 116534573
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 600 KB
Volume: 40
Category: Article
ISSN: 1532-8392
DOI: 10.1016/j.humpath.2008.06.006

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## Abstract We have systematically retrieved genes with coding mononucleotide repeats from sequence databases and analyzed them for mutations in tumors with high levels of microsatellite instability (MSI‐H). We found somatic frameshift mutations in 7/13 genes previously not analyzed in MSI‐H tumors